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KMID : 0870520040080020129
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Journal of Korean Academy of Addiction Psychiatry
2004 Volume.8 No. 2 p.129 ~ p.133
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The Changes of Blood Methanol Concentration during the Experimentally Alcohol-Induced Hangover State
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Yoon Su-Jung
Woo Young-Sup
Lee Hae-Kook
Kim Tae-Hoon
Choi Bo-Moon
Lee Chung-Tai
Kim Dai-Jin
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Abstract
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A hangover is characterized by the constellation of unpleasant physical and mental symptoms that occur between 8 and
16 hours after drinking alcohol. We induced experimental hangover in normal individuals, measured the blood methanol
concent-ration prior to and after alcohol consumption, and assessed the association of the hangover condition and blood
methanol concentration. A total of 13 normal adult males participated in this study. They did not have any previous histories of psychiatric or medical disorders. The blood ethanol concentration prior to the alcohol uptake (3.73±3.95 mg/dL) was not significantly different from that of 13 hours after the alcohol consumption (6.80±8.62 mg/dL). However, the difference of methanol concentration between the day of experiment (prior to the alcohol uptake) and the next day (13 hours after the alcohol uptake) was significant. (2.80±1.72 mg/L Vs 4.82±2.64 mg/L) This result suggest the possible correlation of methanol as well as its toxic metabolite to hangover.
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KEYWORD
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Alcohol, Hangover, Methanol
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